个人简介

边六交，博士，教授，博士生导师，现在皇冠APP下载官网中药学系从事教学和科研工作。目前主要从事药用蛋白分子的克隆表达和分离纯化研究、生物工程和基因工程药物研究、蛋白与特异配体分子间的作用机理研究、超级细菌的金属酶的进化和抗菌机理研究、基于DNA荧光探针的分子和离子检测研究以及微孔淀粉的制备和应用研究等。在中药生物工程和细胞生物工程两个方向招收博士和硕士研究生。

主持科研项目

国家“重大新药创制”科技重大专项项目，基因重组血管生长抑制剂Kringle 5的中试生产工艺和药用研究。

国家自然科学基金面上项目，人纤溶酶原Kringle 5 体内蛋白受体的筛选及它们之间作用机理的研究。

国家自然科学基金面上项目，变性剂诱导的蛋白质分子展开过程稳定构象态分布和转化的理论模型及验证。

陕西省科技统筹创新工程计划项目，微孔淀粉的规模化生产工艺及其止血剂和缓释剂的研究。

主要研究成果

发表论文

Dong Xiaoting, Bai Yifan, Ma Xian, et al. Adsorption and Sustained‐Release Capacity of Glyphosate on Microporous Corn Starch. Starch ‐ Stärke 2021, 73 (7-8), 2000224.

Dong Xiaoting, Xue Pengli, Ma Xian, et al. Recognition and binding of FEZ-1 from Legionella with penicillin V and cefoxitin by fluorescence spectra in combination with molecular dynamics simulation. Enzyme and microbial technology 2021, 149, 109819-109819.

Duan Meijiao, Bai Jiakun, Yang Jian, et al. Screening and identification of bioactive components resistant to metallo-beta-lactamase from Schisandra chinensis (Turcz.) Baill. by metalloenzyme-immobilized affinity chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2021, 1165, 122524-122524.

Zhang Jiaxin, Ma Xian, Chen Wenhua, et al. Bifunctional single-labelled oligonucleotide probe for detection of trace Ag-cytosine mismatches and G-quadruplex. Analytica chimica acta 2021, 1151.

Zhang Jiaxin, Bai Jiakun, Duan Meijiao, et al. Derivation of adsorption capacity and adsorption isotherm by a single adsorbate concentration in liquid-solid system. Chemical papers 2021, 75 (6), 2459-2476.

Zhang Jiaxin, Yang Wenhui, Li Shasha, et al. Fluorescent reversible regulation of cysteamine-capped ZnSe quantum dots successively induced by photoinduced electron transfer of herring sperm DNA and intercalation binding of ethidium bromide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2021, 249.

Zhang Jia-Xin, Zhang Ru-Xue, Liu Wen-Li, et al. Distribution and Transition of Stable Conformations in Unfolding of Bovine Insulin Induced by Urea and Guanidine Hydrochloride. Chinese Journal of Analytical Chemistry 2020, 48 (9), e20114-e20125.

Zhang Yeli, Zhang Ruxue, Bai Jiakun, et al. Human laminin α3 chain G1 domain is a receptor for plasminogen Kringle 5 on human endothelial cells by biological specificity technologies and molecular dynamic. Journal of Chromatography A 2020, 1620, 460986.

Zhang Yeli, Li Yuhua and Bian Liujiao. Design and Unique Expression of a Novel Antibacterial Fusion Protein Cecropin B-Human Lysozyme to Be Toxic to Prokaryotic Host Cells. Probiotics and antimicrobial proteins 2019, 11 (4), 1362-1369.

Zhang Yeli and Bian Liujiao. Recognition and interaction of CphA from Aeromonas hydrophila with imipenem and biapenem by spectroscopic analysis in combination with molecular docking. Journal of molecular recognition 2019, 32 (8), e2781-n/a.

Han Ning, Zhang Zeng-Kuan, Li Yu-Hua, et al. Spectroscopic Analysis of Chloride Ion-induced Structural Change of Bacillus Amyloliquefaciens α-Amylase. Chinese Journal of Analytical Chemistry 2019, 47 (10), e19130-e19138.

Li Yuhua, Zhang Yeli, Zhao Juan, et al. Studies on the Adsorption and Thermodynamics of Theophylline, Vitamin C and Bovine Serum Albumin on Microporous Corn Starch. Starch ‐ Stärke 2019, 71 (3-4), 1800042-n/a.

Zhang Yeli, Zhang Yan, Yang Wenhui, et al. Fluorescent reversible regulation based on photoinduced electron transfer from DNA to quantum dots and intercalation binding of DNA intercalator to DNA. Talanta (Oxford) 2018, 188, 7-16.

Bian Liujiao and Shi Penghui. An Improved Isothermal Adsorption Equation of Gaseous Molecules Under Low Pressure in Gas-Solid System. Journal of phase equilibria and diffusion 2018, 39 (2), 117-128.

Shi Penghui, Zhang Yan, Li Yuhua, et al. Probing the interaction of l‐captopril with metallo‐β‐lactamase CcrA by fluorescence spectra and molecular dynamic simulation. Luminescence (Chichester, England) 2018, 33 (5), 954-961.

Zhang Yeli, Chen Wenhua, Dong Xiaoting, et al. Simultaneous detection of trace toxic metal ions, Pb2+ and Ag+, in water and food using a novel single-labeled fluorescent oligonucleotide probe. Sensors and actuators. B, Chemical 2018, 261, 58-65.

史鹏辉，边六交. 头孢西丁与金属β-内酰胺酶BcⅡ相互作用的光谱分析及分子动力学模拟. 高等学校化学学报 2018, 39 (5), 971-976.

Li Qian, Qiao Pan, Chen Xiu, et al. Affinity chromatographic methodologies based on immobilized voltage dependent anion channel isoform 1 and application in protein-ligand interaction analysis and bioactive compounds screening from traditional medicine. Journal of Chromatography A 2017, 1495, 31-45.

Li Qian, Li Shuaihua, Chen Xiu, et al. A G-quadruplex based fluorescent oligonucleotide turn-on probe towards iodides detection in real samples. Food chemistry 2017, 230, 432-440.

Chen Xiu, Li Yuhua, Zhang Yan, et al. Binding of TEM-1 beta-lactamase to beta-lactam antibiotics by frontal affinity chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2017, 1051, 75-83.

Zhang Yeli, Qiao Pan, Li Shuaihua, et al. Molecular recognition and binding of beta‐lactamase II from Bacillus cereus with penicillin V and sulbactam by spectroscopic analysis in combination with docking simulation. Luminescence (Chichester, England) 2017, 32 (6), 932-941.

Yang Jianting, Li Qian and Bian Liujiao. Spectroscopic analysis and docking simulation on the recognition and binding of TEM-1 beta-lactamase with beta-lactam antibiotics. Experimental and therapeutic medicine 2017, 14 (4), 3288-3298.

Shi Penghui, Qiao Pan, Zhang Yeli, et al. Spectroscopy analysis and molecular dynamics studies on the binding of penicillin V and sulbactam to beta-lactamase II from Bacillus cereus. Journal of pharmaceutical and biomedical analysis 2017, 138, 206-214.

边文海 刘成程 李倩 王超展 边六交. 玉米微孔淀粉制备止血剂研究. 生物技术进展 2017, 7 (4), 320-326.

侯晓苹 李丽 李蕊萍 李帅华 边六交. 马铃薯微孔淀粉的中试生产制备工艺优化. 中国医药工业杂志 2017, 48 (11), 1627-1633.

Li Q., Duan M. J., Li S. S., et al. Recognition and binding of voltage-dependent anion channel-1 with ATP and NADH by spectroscopic analysis and molecular docking. RSC advances 2016, 6 (16), 13407-13417.

Li Qian, Zhang Tianlong and Bian Liujiao. Recognition and binding of β-lactam antibiotics to bovine serum albumin by frontal affinity chromatography in combination with spectroscopy and molecular docking. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2016, 1014, 90-101.

Liang Yin-Ku and Bian Liu-jiao. Voltage- Dependent Anion Channel-1, a Possible Ligand of Plasminogen Kringle 5. PloS one 2016, 11 (10), e0164834-e0164834.

边六交 杨文慧 冀旭. 多方法组合分析脲诱导的淀粉液化芽孢杆菌α-淀粉酶去折叠和重折叠过程的构象转化. 分析科学学报 2016, 32 (1), 8-14.

Bian Liujiao, Li Qian and Ji Xu. Binding of angiogenesis inhibitor kringle 5 to its specific ligands by frontal affinity chromatography. Journal of Chromatography A 2015, 1401, 42-51.

Liang Yin-Ku, Ping Wei and Bian Liu-Jiao. Cloning, expression and identification of an isoform of human stromal cell derived factor-1 alpha. Experimental and therapeutic medicine 2015, 9 (5), 1751-1756.

Li Qian, Wang Jing, Yang Lingjian, et al. Estimation of interaction between oriented immobilized green fluorescent protein and its antibody by high performance affinity chromatography and molecular docking. Journal of molecular recognition 2015, 28 (7), 438-446.

Bian Liujiao, Yang Jianting and Sun Yu. Isolation and purification of monosialotetrahexosylgangliosides from pig brain by extraction and liquid chromatography: Isolation and purification of GM1. Biomedical chromatography 2015, 29 (10), 1604-1611.

侯晓苹 赵娟 侯晓莉 李帅华 边六交. 维生素C、茶碱和BSA在微孔淀粉上的吸附/释放动力学考察. 中国医药工业杂志2015, 46 (8), 860-865.

Bian Liujiao and Ji Xu. Distribution, Transition and Thermodynamic Stability of Protein Conformations in the Denaturant-Induced Unfolding of Proteins. PloS one 2014, 9 (3), e91129-e91129.

Bian Liujiao, Ji Xu and Hu Wei. Isolation and purification of recombinant human plasminogen Kringle 5 by liquid chromatography and ammonium sulfate salting-out. Biomedical chromatography 2014, 28 (7), 957-965.

Bian Liujiao, Ji Xu and Hu Wei. A Novel Single-Labeled Fluorescent Oligonucleotide Probe for Silver(I) Ion Detection in Water, Drugs, and Food. Journal of agricultural and food chemistry 2014, 62 (21), 4870-4877.

Ji Xu, Ma Xiaojuan and Bian Liujiao. Spectral Studies on the Conformational Transitions of Bovine Insulin During Denaturant-induced Unfolding. Chemical research in Chinese universities 2014, 30 (2), 222-227.

Bian Liujiao, Wu Dan and Hu Wei. Temperature-induced conformational transition of bovine serum albumin in neutral aqueous solution by reversed-phase liquid chromatography: Temperature-induced conformational transition of BSA. Biomedical chromatography 2014, 28 (2), 295-301.

Bian Liujiao, Ji Xu and Hu Wei. Urea-Induced Dissociation of Nerve Growth Factor from Venom of Chinese Cobra by SEC. Chromatographia 2014, 77 (11-12), 793-802.

边六交 吴丹. 光谱法研究变性剂诱导的猪胃蛋白酶和牛血清蛋白折叠中间态的分布和过渡. 分析科学学报 2014, 30 (1), 31-34.

发明专利

[1] 边六交，蔚萍，冀旭，侯俊。人源基质细胞衍生因子1α的表达载体、构建方法及应用，专利号：CN201310253558.6。

[2] 边六交，刘成程，冀旭。一种高比表面积微孔淀粉的制备方法，专利号：CN201110288482.1。

[3] 边六交，妙亮。 一种高活性可溶型血管生长抑制剂Kringle 5三聚体的高效表达方法，专利号：CN201010298771.5。

       [4] 边文海，李倩，陈秀，王超展，边六交。一种快速止血剂，专利号：CN201610996028.4。