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贾璞
发布时间:2020-05-21      作者:    点击:[]    分享到:

个人简介

研究方向:中药复方代谢及分析研究
通信地址:皇冠APP下载官网,西安市太白北路229号,邮编 710069
 Tel: 029-88302686
(办公室)
 Fax: 029-88302686

教育及工作经历
2002
年-2006年,陕西中医药大学,药学院,医学学士学位
2006
年-2009年,陕西中医药大学,药学院,医学硕士学位
2009
—2013年,皇冠APP下载官网,皇冠APP下载官网,医学博士学位
2013
年-2016年,皇冠APP下载官网,皇冠APP下载官网,博士后
2016
年-至今, 皇冠APP下载官网,皇冠APP下载官网,教 师

承担的科研项目

1. 国家自然科学基金项目:
基于微透析-代谢组学-因果辨识数理模型的丹参-降香抗脑缺血再灌注损伤效应物质研究(编号:81603259),起止时间:2017.01-2019.12 ,项目负责人;

2. 陕西省自然科学基金项目:
MD-M-MC
技术研究丹参-红花抗脑缺血再灌注损伤效应物质(编号:2019JQ-725),
 
起止时间:2019.01-2020.12 ,项目负责人;
4. 2015
年教育部“创新团队发展计划”滚动支持:
“基于秦巴优势生物资源的生命效应分析与新药创制研究(编号: IRT_15R55)”团队
起止时间:2016.01-2018.12,项目参与人;

5.国家自然科学基金项目:

基于“品、质、性、 效、用”一体化评价模式的大果飞蛾藤代用丁公藤可行性研究(编号:81973419

起止时间:2020.01-2023.12,项目参与人;
6.
国家自然科学基金项目:
基于血小板P2Y12受体色谱技术探究典型活血化瘀中药药效物质研究(编号:81303185)起止时间:2014.01-2016.12,项目参与人;
7.
陕西省重点科技创新团队计划:
基于秦巴优势中草药资源的新药创制研究(编号:2013KCT-24
起止时间:2013.7-2016.7,项目参与人;
8.
国家科技部科技支撑计划项目:
中药有效成分群关键技术研究(编号:2008BAI51B01
起止时间:2011.03-2013/12,项目参与人;
9.
国家自然科学基金项目:
植物药中酚酸活性成分协同效应机制的NMR研究(编号:21005062
起止时间:2011.01 -2013.12,项目参与人;

主要研究成果

一、研究论文

1. Pu Jia, Shixiang Wang, Chaoni Xiao*, Lumeng Yang, Yongyong Chen, Wei Jiang, Xiaopu Zheng, Guifang Zhao, Weijin Zang* , Xiaohui Zheng*. The anti-atherosclerotic eect of tanshinone borneol ester using fecal metabolomics based on liquid chromatography-mass spectrometry. Analyst, 2016, 141, 1112 - 1120.
2. Pu Jia, Shixiang Wang **, Xue Meng, Wei Lan, Jing Luo, Sha Liao, Chaoni Xiao, Xiaopu Zheng, Lianshe Li, Qinshe Liu, Jianbin Zheng, Yuanzhen Zhou, Xiaohui Zheng*. Effects of ionic liquid and nanogold particles on high-performance liquid chromatography -electrochemical detection and their application in highly efficient separation and sensitive analysis of five phenolic acids in Xuebijing injection, Talanta. 2013,107:103-110.

3.Baimei Shi, Qiannan Li, Ying Feng, Xufen Dai, Rui Zhao, Ye Zhao, Pu Jia*, Shixiang Wang, Jie Yu, Sha Liao, Yi-fei Li, Xiaohui Zheng*. Pharmacokinetics of 13 active components in a rat model of middle cerebral artery occlusion after intravenous injection of Radix salviae miltiorrhizae-Lignum dalbergiae odoriferae prescriptionJournal of Separation Science201943(2):531-546

4. Jie Wang, Cuicui Ma#, Qiannan Li, Xing Wang, Yang Yang, Lingjian Yang, Wei Jiang, Sha Liao, Shixiang Wang*, Pu Jia*, Ye Zhao, Xiaohui Zheng. Metabolites identification of Tanshinol Borneol Ester in rats by high performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry, Biomedical Chromatography, 2019, 33(3)e4438.

5. Baimei Shi, Lingjian Yang, Tian Gao, Cuicui Ma, Qiannan Li, Yefei Nan, Shixiang Wang, Chaoni Xiao, Pu Jia*, Xiaohui Zheng*.Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry, RSC Advance, 2019, 9, 4015-4027.

6. Zhenghong Hua, Pu Jia#, Yajun Bai, Tai-ping Fan, Xiaohui Zheng*, Yujie Cai*. Characterisation of five alcohol dehydrogenases from Lactobacillus reuteri DSM20016. Process Biochemistry , 2019, 86:73-39.

7. Chaozhi Li, Pu Jia#, Yajun Bai, Tai-ping Fan, Xiaohui Zheng*, Yujie Cai*. Efficient Synthesis of Hydroxytyrosol from L 3,4-Dihydroxyphenylalanine Using Engineered Escherichia coli Whole

Cells. Journal of Agriculture and Food Chemistry, 2019, 67, 68676873.

8. Tianzhen Xiong, Pu jia#, Jing Jiang, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng*, Yujie Cai*. One-pot, three-step cascade synthesis of D-danshensu using engineered Escherichia coli whole cells. Journal of Biotechnology, 2019 :48–54.

9. Yi Yan, Pu Jia#, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng*, Yujie Cai*. Production of rosmarinic acid with ATP and CoA double regenerating system. Enzyme and Microbial Technology, 2019, 131:109392-109397.

10. 郑晓晖*, 贾璞, 白亚军. 基于传统君臣佐使组方配伍理论的组合中药分子化学研究策略. 皇冠APP下载官网学报(自然科学版), 2015, 453: 406-41.
11. Lingjian Yang, Pu Jia, Qian Li, Shixiang Wang, Jing Wang, Yajun Bai, Xiaoxiao Wang, Chaoni Xiao, Jie Yu, Peng Zhang, Xiaohui Zheng*. Identification of metabolites of isopropyl 3-(3, 4-dihydroxyphenyl) -2- hydroxypropanoate in rats by high performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Biomedical Chromatography, 2016, 30(7):1042-1051.
12. Chaoni Xiao, Pu Jia, Man Wu, Yajun Zhang, Shixiang Wang, Xinfeng Zhao, Xiaohui Zheng*. Cold water forced swimming stress induced metabolic alterations in rats. Analytical Methods, 2014, 6: 4144-4151.

二、发明专利

郑晓晖; 白亚军; 贾璞; 张亚军; 廖莎;IDHP制备预防和治疗冠状动脉粥样硬化疾病药物的应用,, ZL.201610876752.3.

三、科研奖励

1. 陕西高等学校科学技术奖一等奖,基于“良关系”的组合中药分子化学新药研发策略的构建及

基础应用,第三完成人,陕西省教育厅,2018

2. 陕西高等学校科学技术奖二等奖,“气血互济,益化相融”中药相关功能食品的研究与产业化,第二完成人,陕西省教育厅,2017

3. 省中医药优秀中青年科技骨干人才,2020

 

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